Methicol IV/IM Injection

✔️ Uses of Methicol IV/IM Injection

• Peripheral Neuropathies
• Diabetic Neuropathy
• Vertebral Syndrome
• Nerve Compression Syndrome
• Multiple sclerosis
• Amyotrophic lateral sclerosis
• Parkinson’s disease
• Alzheimer’s disease
• Diabetic retinopathy
• Entrapment neuropathy
• Drug-induced neuropathy
• Megaloblastic anemia due to Vitamin B12 deficiency

✔️ How does Methicol IV/IM Injection work?

Methicol IV/IM Injection is a form of vitamin B12 that restores its level in the body thereby helping in treating certain anemias and nerve problems.

✔️ Side Effects of Methicol IV/IM Injection

• Painfulness or tenderness at the injection site
• Nausea
• Vomiting
• Diarrhea
• Loss of appetite
• Headache

✔️ Quick Suggestions:

• Methicol IV/IM Injection helps replenish vitamin B12 levels in your body.
• Drink milk and make cheese and yogurt in your diet.
• Take eggs, meat, and fish into your diet.
• Avoid oily and canned foods.
• Avoid tea and coffee.
• This further helps in the regeneration of damaged nerves in the body.
• Avoid or limit alcohol consumption while taking this medication.

✔️ Indication

Vitamins are indeed essential for the proper functioning of our body, and their deficiency can lead to various health issues. Vitamin B-12 deficiency, in particular, can result in peripheral neuropathy and megaloblastic anemia, both of which have significant health implications.

• Peripheral neuropathy is a condition characterized by damage to the nerves responsible for transmitting messages between the brain, spinal cord, and the rest of the body. If left untreated, it can lead to permanent nerve damage and a range of neurological problems.
• Megaloblastic anemia is a type of blood disorder where there is a lower-than-normal level of red blood cells. Red blood cells play a crucial role in transporting oxygen to tissues and organs. In megaloblastic anemia, the red blood cells are larger than normal and are not produced correctly, leading to reduced oxygen delivery to the body's tissues and organs.

Both of these conditions can have a significant impact on a person's overall health and well-being, underscoring the importance of maintaining adequate vitamin levels through a balanced diet or, if necessary, vitamin supplementation under medical supervision.

✔️ Pharmacology

Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting the maturation and division of erythrocytes.

✔️ Dosage & Administration of Methicol IV/IM Injection

Peripheral Neuropathies:

• Usual Adult Dosage: 500 mcg of Mecobalamin
• Administration: Intramuscularly or intravenously
• Frequency: Three times a week
• Dosage Adjustment: The dosage should be adjusted based on the age of the patient and the severity of symptoms.

Megaloblastic Anemia:

• Usual Adult Dosage: 500 mcg of Mecobalamin
• Administration: Intramuscularly or intravenously
• Frequency: Three times a week initially
• Maintenance Therapy: After about two months of administration, the dosage should be changed to one ampoule equivalent to 500 mcg of Mecobalamin every one to three months.

It's important to note that Mecobalamin injections should be administered by a qualified healthcare professional. Self-administration is not recommended. The healthcare provider will determine the appropriate dosage and frequency based on the patient's condition and individual factors.

✔️ Interaction

Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers, and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anemia with parenteral chloramphenicol.

✔️ Contraindications

Hypersensitivity to any component of this product.

✔️ Pregnancy & Lactation

Not recommended during pregnancy & lactation.

✔️ Precautions & Warnings

• Do not consume Mecobalamin if you are allergic to any of its ingredients.
• To effectively treat your condition, continue taking Mecobalamin for the full duration prescribed by your doctor. Do not stop taking it without consulting your doctor.
• Do not take Mecobalamin if you are pregnant or breastfeeding unless it has been prescribed by your doctor. Always consult with your healthcare provider in these situations.
• If Mecobalamin is prescribed for children, follow your doctor's advice on the appropriate dosage and administration.
• Inform your doctor if you have low potassium levels in the blood, iron deficiency, or folic acid deficiency. Your healthcare provider may need to consider these factors in your treatment plan.
• If you have a history of optic nerve damage, it's essential to inform your doctor. They can take this into account when prescribing and monitoring your treatment.

Keep your doctor informed about your overall health condition and any other medications you may be taking. This helps ensure that your treatment plan is safe and effective.

✔️ Storage Conditions

Store at room temperature. Protect from moisture and light.